When is it safe to say it's not hormones?

People make the "umption" that it's hormones because after thousands of years people have realized that it's often hormones. People go through a great deal of depression and confusion during puberty, PMS, post-partum depression and menopause. All hormones. Young people experience a desire for maturity when their hormones mature, yet society does not grant it to them until they fulfill artificial expectations - a certain age, education, graduation, etc. Your body, mind, and societal expections don't agree - leading to depression, hostility and conflict. What makes you think hormones are not the cause?